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PD 089828
CAS No. 179343-17-0
PD 089828 ( PD-089828; PD089828 )
Catalog No. M23806 CAS No. 179343-17-0
PD 089828 is a competitive inhibitor of the receptor tyrosine kinases FGFR1, PDGFRβ, and EGFR (IC50s = 0.15, 1.76, and 5.47 μM, respectively) and a noncompetitive inhibitor of the nonreceptor tyrosine kinase c-Src (IC50 = 0.18 μM)
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 65 | In Stock |
|
| 10MG | 110 | In Stock |
|
| 25MG | 237 | In Stock |
|
| 50MG | 354 | In Stock |
|
| 100MG | 518 | In Stock |
|
| 500MG | 1098 | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NamePD 089828
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NoteResearch use only, not for human use.
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Brief DescriptionPD 089828 is a competitive inhibitor of the receptor tyrosine kinases FGFR1, PDGFRβ, and EGFR (IC50s = 0.15, 1.76, and 5.47 μM, respectively) and a noncompetitive inhibitor of the nonreceptor tyrosine kinase c-Src (IC50 = 0.18 μM)
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DescriptionPD 089828 is a competitive inhibitor of the receptor tyrosine kinases FGFR1, PDGFRβ, and EGFR (IC50s = 0.15, 1.76, and 5.47 μM, respectively) and a noncompetitive inhibitor of the nonreceptor tyrosine kinase c-Src (IC50 = 0.18 μM)
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SynonymsPD-089828; PD089828
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PathwayAngiogenesis
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TargetEGFR
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RecptorEGFR;FGFR1;PDGFRβ
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Research Area——
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Indication——
Chemical Information
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CAS Number179343-17-0
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Formula Weight405.3
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Molecular FormulaC18H18Cl2N6O
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Purity>98% (HPLC)
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SolubilityDMSO:2.5 mM
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SMILESCC(C)(C)NC(=O)NC1=C(C=C2C=NC(=NC2=N1)N)C3=C(C=CC=C3Cl)Cl
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1.Dahring TK, et al. Inhibition of growth factor-mediated tyrosine phosphorylation in vascular smooth muscle by PD 089828, a new synthetic protein tyrosine kinase inhibitor. J Pharmacol Exp Ther. 1997 Jun;281(3):1446-56.
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