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PD 089828

CAS No. 179343-17-0

PD 089828 ( PD-089828; PD089828 )

Catalog No. M23806 CAS No. 179343-17-0

PD 089828 is a competitive inhibitor of the receptor tyrosine kinases FGFR1, PDGFRβ, and EGFR (IC50s = 0.15, 1.76, and 5.47 μM, respectively) and a noncompetitive inhibitor of the nonreceptor tyrosine kinase c-Src (IC50 = 0.18 μM)

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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5MG 65 In Stock
10MG 110 In Stock
25MG 237 In Stock
50MG 354 In Stock
100MG 518 In Stock
500MG 1098 In Stock
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Biological Information

  • Product Name
    PD 089828
  • Note
    Research use only, not for human use.
  • Brief Description
    PD 089828 is a competitive inhibitor of the receptor tyrosine kinases FGFR1, PDGFRβ, and EGFR (IC50s = 0.15, 1.76, and 5.47 μM, respectively) and a noncompetitive inhibitor of the nonreceptor tyrosine kinase c-Src (IC50 = 0.18 μM)
  • Description
    PD 089828 is a competitive inhibitor of the receptor tyrosine kinases FGFR1, PDGFRβ, and EGFR (IC50s = 0.15, 1.76, and 5.47 μM, respectively) and a noncompetitive inhibitor of the nonreceptor tyrosine kinase c-Src (IC50 = 0.18 μM)
  • Synonyms
    PD-089828; PD089828
  • Pathway
    Angiogenesis
  • Target
    EGFR
  • Recptor
    EGFR;FGFR1;PDGFRβ
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    179343-17-0
  • Formula Weight
    405.3
  • Molecular Formula
    C18H18Cl2N6O
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO:2.5 mM
  • SMILES
    CC(C)(C)NC(=O)NC1=C(C=C2C=NC(=NC2=N1)N)C3=C(C=CC=C3Cl)Cl
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Dahring TK, et al. Inhibition of growth factor-mediated tyrosine phosphorylation in vascular smooth muscle by PD 089828, a new synthetic protein tyrosine kinase inhibitor. J Pharmacol Exp Ther. 1997 Jun;281(3):1446-56.
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